Ketones are a marker for chronic stress in tumor bearing animals.
Biokhimiia. 1987 Sep;52(9):1501-11.
[Activation of lipolysis and ketogenesis in tumor-bearing animals as a reflection of chronic stress states].
[Article in Russian]
Chekulaev VA, Shelepov VP, Pasha-zade GR, Shapot VS.
I understand your concerns b/c when you start to read Dr. Peat's it will turn your world upside down yet at the same time maybe correlate directly to yourself or someone you know making it very intriguing. This causes some brain hurt and may require some relearning and questioning. I will try my best to answer your concerns.
Virtually every single thing Dr. Peat writes about is science based and nothing is based on being trendy or what industry or mainstream dictates. He's not pulling this material out of hat. When he adds his two cents, it's logical and sensical. His worked is based on hundreds of other researchers so when you say Dr. Peat you are also mentioning other researchers who sometimes utilize simple and effective means of health preservation or correction. If you're looking for backing, look at his resources. Research the people he's researched. This information is all 100% transparent. He has several article regarding cancer so those would be good to read. My blog provides research on various topics supporting Dr. Peat's work or based directly on his writings.
Sugar consumption is not the cause of cancer. Cancer is a respiratory defect (see Warburg Effect) and another expression of the outcome of the low energy state of the organism. Glucose is the preferred fuel by all trillion of your cells. Glucose is needed for oxidative metabolism, which is the most efficient and powerful means of creating energy and CO2 in your body. You can make glucose by other means, however, these other means take energy, produce less energy, and are ultimately inefficient in comparison. This is all basic stuff.http://www.functionalps.com/blog/2011/1 ... at-a-cost/
Glucose restriction leads to the stress metabolism that is inefficient, low energy, decreases oxygen consumption, and mimics that of cancer - increased lactic acid, less CO2, rise in adrenaline and cortisol which depletes progesterone and lowers metabolism, depletion of glycogen, conversion of protein to glucose, oxidation of fat and protein, high PUFA which block glucose oxidation (Randle Effect), high inflammation, high endotoxin exposure (leaky intestines), low thyroid, tissue wasting (like cachexia), etc. There are many between the low carber and the cancer patient, after-all they are both in a chronic stress state.
The major premise of Dr. Peat's work in my eyes is maximize biological energy production which increases production of the protective substances while decreasing the degenerative factors. Dr. Peat's work is protective because it encourages oxidative metabolism and oxygen consumption, supports production of anti-cancer steroids (like pregnenolone and progesterone) from cholesterol, balances blood sugar, provides much vitamin and mineral nourishment from traditional foods which promote a high energy state, reduces endotoxicity, decreases PUFA and iron consumption (which are carcinogenic in excess), and support thyroid/metabolic function and the production of CO2 (which oxygenates the tissues).
When protective factors check or offset the inflammatory factors, the body's resiliency is high; however, when these tables turn is when things can start to breakdown as the organism no longer has the means available to positively adapt to the stressor(s). As Dr. Peat puts it -- "Cancer metabolism" or stress metabolism typically involves an excess of the adaptive hormones, resulting from an imbalance of the demands made on the organism and the resources available to the organism.
Below is a glossary of terms that may help. From: http://raypeat.com/articles/articles/lactate.shtml
Aerobic glycolysis, the conversion of glucose to lactic acid even in the presence of oxygen. The presence of oxygen normally restrains glycolysis so that glucose is converted to carbon dioxide instead of lactic acid.
Anaerobic glycolysis, the increased conversion of glucose to lactic acid when the supply of oxygen isn't sufficient, which is a normal event during intense muscle action.
"Warburg Effect" refers to Otto Warburg's observation that cancer cells produce lactic acid even in the presence of adequate oxygen. Cancer cells don't "live on glucose," since they are highly adapted to survive on protein and fats.
Pasteur Effect, the normal response of cells to restrain glycolysis in the presence of adequate oxygen.
Crabtree Effect, observed originally in yeast, refers to the inhibition of respiration in the presence of glucose. This occurs in cancers (e.g., Miralpeix, et al., 1990) and in rapidly proliferating normal cells (e.g., Guppy, et al., 1993).
"Cancer metabolism" or stress metabolism typically involves an excess of the adaptive hormones, resulting from an imbalance of the demands made on the organism and the resources available to the organism. Excessive stimulation depletes glucose and produces lactic acid, and causes cortisol to increase, causing a shift to the consumption of fat and protein rather than glucose. Increased cortisol activates the Randle effect (the inhibition of glucose oxidation by free fatty acids), accelerates the breakdown of protein into amino acids, and activates the enzyme fatty acid synthase, which produces fatty acids from amino acids and pyruvate, to be oxidized in a "futile cycle," producing heat, and increasing the liberation of ammonia from the amino acids. Ammonia suppresses respiratory, and stimulates glycolytic, activity.