{"id":3762,"date":"2011-12-16T10:22:31","date_gmt":"2011-12-16T18:22:31","guid":{"rendered":"http:\/\/www.functionalps.com\/blog\/?p=3762"},"modified":"2012-07-13T08:03:02","modified_gmt":"2012-07-13T15:03:02","slug":"lipid-peroxidation-decreases-progesterone-synthesis","status":"publish","type":"post","link":"https:\/\/www.functionalps.com\/blog\/2011\/12\/16\/lipid-peroxidation-decreases-progesterone-synthesis\/","title":{"rendered":"Lipid Peroxidation Decreases Progesterone Synthesis"},"content":{"rendered":"<p>Also see:<br \/>\n<a href=\"https:\/\/www.functionalps.com\/blog\/2012\/01\/15\/pufa-accumulation-aging\/\">PUFA Accumulation &#038; Aging<\/a><br \/>\n<a href=\"https:\/\/www.functionalps.com\/blog\/2012\/01\/10\/fish-oil-and-lipid-peroxidation\/\">Fish Oil and Lipid Peroxidation<\/a><\/p>\n<p><em>If our purpose is to delay the menopausal rise of the gonadotrophins, then it is interesting that lipid peroxidation of polyunsaturated fatty acids (which <a href=\"https:\/\/www.functionalps.com\/blog\/2012\/01\/15\/pufa-accumulation-aging\/\">increases with age<\/a>) can be intimately involved in loss of progesterone forming ability by human steroidogenic tissues.<\/em> -Ray Peat, PhD<\/p>\n<p><a href=\"https:\/\/www.functionalps.com\/blog\/wp-content\/uploads\/2011\/12\/Picture-11.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-medium wp-image-3767\" title=\"Picture 1\" src=\"https:\/\/www.functionalps.com\/blog\/wp-content\/uploads\/2011\/12\/Picture-11-300x251.png\" alt=\"\" width=\"300\" height=\"251\" srcset=\"https:\/\/www.functionalps.com\/blog\/wp-content\/uploads\/2011\/12\/Picture-11-300x251.png 300w, https:\/\/www.functionalps.com\/blog\/wp-content\/uploads\/2011\/12\/Picture-11.png 593w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><br \/>\n<center><em>http:\/\/en.wikipedia.org\/wiki\/File:Biosynthesis_progesterone.png<\/em><\/center><\/p>\n<p>J Steroid Biochem Mol Biol. 1992 Aug;42(7):729-36.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/1504011\"><strong>The influence of NADPH-dependent lipid peroxidation on the progesterone biosynthesis in human placental mitochondria.<\/strong><br \/>\n<\/a>Klimek J.<br \/>\nIn an in vitro system consisting of human term placental mitochondria and an NADPH-generating system plus Fe2+, <strong>significant lipid peroxidation was observed along with a concomitant inhibition of progesterone biosynthesis. This inhibition could be markedly blocked by Mn2+, superoxide dismutase and dimethylfuran, inhibitors of NADPH-dependent lipid peroxidation.<\/strong> In addition, it has been found that <a href=\"http:\/\/en.wikipedia.org\/wiki\/Malondialdehyde\">malondialdehyde<\/a> formation is accompanied by a corresponding decrease in placental mitochondrial cytochrome P-450 content. <strong>Inhibitors of lipid peroxidation also prevent the loss of cytochrome P-450, further demonstrating a direct relationship between NADPH-dependent lipid peroxidation and degradation of cytochrome P-450 in cell-free systems. These measurements provide the first evidence that the inhibition of progesterone biosynthesis by a NADPH-dependent lipid peroxidation in placental mitochondria is a consequence of cytochrome P-450 degradation due to lipid peroxidation.<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Also see: PUFA Accumulation &#038; Aging Fish Oil and Lipid Peroxidation If our purpose is to delay the menopausal rise of the gonadotrophins, then it is interesting that lipid peroxidation of polyunsaturated fatty acids (which increases with age) can be intimately involved in loss of progesterone forming ability by human steroidogenic tissues. -Ray Peat, PhD [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-3762","post","type-post","status-publish","format-standard","hentry","category-general"],"_links":{"self":[{"href":"https:\/\/www.functionalps.com\/blog\/wp-json\/wp\/v2\/posts\/3762","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.functionalps.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.functionalps.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.functionalps.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.functionalps.com\/blog\/wp-json\/wp\/v2\/comments?post=3762"}],"version-history":[{"count":12,"href":"https:\/\/www.functionalps.com\/blog\/wp-json\/wp\/v2\/posts\/3762\/revisions"}],"predecessor-version":[{"id":6236,"href":"https:\/\/www.functionalps.com\/blog\/wp-json\/wp\/v2\/posts\/3762\/revisions\/6236"}],"wp:attachment":[{"href":"https:\/\/www.functionalps.com\/blog\/wp-json\/wp\/v2\/media?parent=3762"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.functionalps.com\/blog\/wp-json\/wp\/v2\/categories?post=3762"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.functionalps.com\/blog\/wp-json\/wp\/v2\/tags?post=3762"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}