{"id":4407,"date":"2012-02-29T11:15:53","date_gmt":"2012-02-29T19:15:53","guid":{"rendered":"http:\/\/www.functionalps.com\/blog\/?p=4407"},"modified":"2013-03-23T09:40:16","modified_gmt":"2013-03-23T16:40:16","slug":"progesterone-and-protection-from-carrageenan","status":"publish","type":"post","link":"https:\/\/www.functionalps.com\/blog\/2012\/02\/29\/progesterone-and-protection-from-carrageenan\/","title":{"rendered":"Progesterone and Protection from Carrageenan"},"content":{"rendered":"

Also see:
\nCarrageenan, Inflammation, Cancer, Immunity<\/a>
\nCarrageenan: A pseudo-latex allergy<\/a>
\nDoubts surface about safety of common food additive, carrageenan<\/a>
\nCarrageenan: How a “Natural” Food Additive is Making Us Sick<\/a><\/p>\n

Jpn J Pharmacol. 1979 Aug;29(4):509-14.
\nAnti-inflammatory action of progesterone on carrageenin-induced inflammation in rats.<\/a>
\n<\/strong>Nakagawa H, Min KR, Nanjo K, Tsurufuji S.
\nEffect of progesterone (1 mg\/kg) on the inflammation in rats induced by carrageenin was studied. Progesterone inhibited the vascular permeability and the formation of granulation tissue in the early phase of the inflammation. In the chronic proliferative phase, progesterone suppressed the vascular permeability and there was an active resorption of the granulation tissue. Increased degradation of noncollagen protein was observed in the treated group without apparent influence on the metabolism of collagen or on the synthesis of noncollagen protein. The mode of action of progesterone was compared with that of a potent anti-inflammatory steroid, hydrocortisone acetate.<\/p>\n

\"\"<\/a><\/p>\n

Biochemical Pharmacology Volume 30, Issue 6, 15 March 1981, Pages 639\u2013644
\nAnti-inflammatory action of progesterone and its possible mode of action in rats<\/a>
\n<\/strong>Nakagawa Hideo, Kyung Rak Min\u2020, Tsurufuji Susumu
\nThe effect of progesterone on carrageenin-induced paw edema was studied in rats. Repeated injections of progesterone (1 mg\/kg body weight) were given subcutaneously every 12 hr; the swelling of the paw edema was significantly inhibited by five, seven and nine injections of progesterone, whereas three injections of progesterone caused a significant inhibition at 1 hr only after carrageenin injection into the hind paw.<\/strong> \u03b11 Macroglobulin (\u03b11 M) was purified by gel filtration on Sephadex G-200 and DEAE-cellulose column chromatography from the pooled sera of rats injected repeatedly with progesterone (1 mg\/kg body weight) or the vehicle (sesame oil). The trypsin-inhibiting capacity of the \u03b11 M fraction from the progesterone-treated group was about twice as high as that from the control group. The anti-inflammatory action of the purified \u03b11 M from the serum of the progesterone-treated rats was studied; the swelling of carrageenin-induced paw edema was significantly inhibited for 1\u20132 hr after carrageenin injection, and this effect became progressively less pronounced over 3\u20134 hr when a single intravenous injection of the purified \u03b11 M fraction (19 mg protein\/rat) was given immediately before the carrageenin injection into the hind paw. A granuloma pouch was induced by the injection of a 2% carrageenin solution into a pre-formed air pouch on the back of rats and the purified \u03b11 M (70 mg protein\/kg body weight) was injected into the air pouch immediately after the carrageenin injection, with the result that a single injection of the purified \u03b11 M significantly inhibited the formation of granulation tissue on day 4 after the carrageenin injection. These results suggest that progesterone exerts its anti-inflammatory action through an increased protease-inhibiting activity of \u03b11 M<\/strong>, although anti-inflammatory action of the purified \u03b11 M from vehicle-treated rat serum, alone, was not examined.<\/p>\n","protected":false},"excerpt":{"rendered":"

Also see: Carrageenan, Inflammation, Cancer, Immunity Carrageenan: A pseudo-latex allergy Doubts surface about safety of common food additive, carrageenan Carrageenan: How a “Natural” Food Additive is Making Us Sick Jpn J Pharmacol. 1979 Aug;29(4):509-14. Anti-inflammatory action of progesterone on carrageenin-induced inflammation in rats. Nakagawa H, Min KR, Nanjo K, Tsurufuji S. Effect of progesterone (1 […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[979,100,6],"class_list":["post-4407","post","type-post","status-publish","format-standard","hentry","category-general","tag-carrageenan","tag-inflammation","tag-progesterone"],"_links":{"self":[{"href":"https:\/\/www.functionalps.com\/blog\/wp-json\/wp\/v2\/posts\/4407","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.functionalps.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.functionalps.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.functionalps.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.functionalps.com\/blog\/wp-json\/wp\/v2\/comments?post=4407"}],"version-history":[{"count":5,"href":"https:\/\/www.functionalps.com\/blog\/wp-json\/wp\/v2\/posts\/4407\/revisions"}],"predecessor-version":[{"id":8852,"href":"https:\/\/www.functionalps.com\/blog\/wp-json\/wp\/v2\/posts\/4407\/revisions\/8852"}],"wp:attachment":[{"href":"https:\/\/www.functionalps.com\/blog\/wp-json\/wp\/v2\/media?parent=4407"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.functionalps.com\/blog\/wp-json\/wp\/v2\/categories?post=4407"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.functionalps.com\/blog\/wp-json\/wp\/v2\/tags?post=4407"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}