{"id":6082,"date":"2012-06-30T08:06:16","date_gmt":"2012-06-30T15:06:16","guid":{"rendered":"http:\/\/www.functionalps.com\/blog\/?p=6082"},"modified":"2012-06-30T08:10:00","modified_gmt":"2012-06-30T15:10:00","slug":"factors-that-can-lower-tsh","status":"publish","type":"post","link":"https:\/\/www.functionalps.com\/blog\/2012\/06\/30\/factors-that-can-lower-tsh\/","title":{"rendered":"Factors That Can Lower TSH"},"content":{"rendered":"<p><em>Aging, infection, trauma, prolonged cortisol excess, somatostatin, dopamine or L-dopa, adrenaline (sometimes; Mannisto, et al., 1979), amphetamine, caffeine and fever can lower TSH, apart from the effect of feedback by the thyroid hormones, creating a situation in which TSH can appear normal or low, at the same time that there is a real hypothyroidism.<\/em> -Ray Peat, PhD<\/p>\n<p>Acta Endocrinol (Copenh). 1979 Feb;90(2):249-58.<br \/>\n<strong><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/105532\">Dual action of adrenergic system on the regulation of thyrotrophin secretion in the male rat.<\/a><br \/>\n<\/strong>M\u00e4nnist\u00f6, Ranta T, Tuomisto J.<br \/>\nThe effect of graded doses of drugs modifying adrenergic activity on basal and cold-stimulated TSH secretion was studied in male rats. alpha-methyl-p-tyrosine (aMPT) (16 h before 30 min cold-exposure), phenoxybenzamine (1 h), Ca-fusarate (1 h) and diethyldithiocarbamate (DDC) (1 and 18 h) dose-dependently depressed the cold-stimulated TSH secretion. The effect of reserpine (24 h) was not significant. <strong>Clonidine (1 h), dihydroxyphenyl-serine (DOPS) (1 h), noradrenaline (NA) (1 h), and L-Dopa (1 h) were also effective in decreasing serum TSH levels<\/strong>, but dopamine (DA) (ad 2 mg\/kg, 1 h) had no effect. Basal TSH levels were also decreased by various doses of clonidine, DOPS and NA, given ip 1 h before sacrifice. Clonidine (1 mg\/kg), NA (1 mg\/kg), DA (2 mg\/kg), aMPT (300 mg\/kg), phenoxybenzamine (2 or 20 mg\/kg), Ca-fusarate (50 mg\/kg) or L-Dopa (200 mg\/kg) did not modify the TRH-induced TSH response. <strong>These results cannot be explained by assuming only a stimulatory function for the adrenergic system on the secretion of TSH in the rat.<\/strong> The site of the possible inhibitory function of noradrenaline in the control of TSH cannot be deduced from these results, but various possibilities are discussed.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Aging, infection, trauma, prolonged cortisol excess, somatostatin, dopamine or L-dopa, adrenaline (sometimes; Mannisto, et al., 1979), amphetamine, caffeine and fever can lower TSH, apart from the effect of feedback by the thyroid hormones, creating a situation in which TSH can appear normal or low, at the same time that there is a real hypothyroidism. -Ray [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[456,367,1287,62,144,164,685,536,142,1513,589],"class_list":["post-6082","post","type-post","status-publish","format-standard","hentry","category-general","tag-adrenaline","tag-aging","tag-caffeine","tag-coffee","tag-cortisol","tag-hypothyroid","tag-infection","tag-pituitary","tag-thyroid","tag-thyroid-stimulating-hormone","tag-tsh"],"_links":{"self":[{"href":"https:\/\/www.functionalps.com\/blog\/wp-json\/wp\/v2\/posts\/6082","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.functionalps.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.functionalps.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.functionalps.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.functionalps.com\/blog\/wp-json\/wp\/v2\/comments?post=6082"}],"version-history":[{"count":2,"href":"https:\/\/www.functionalps.com\/blog\/wp-json\/wp\/v2\/posts\/6082\/revisions"}],"predecessor-version":[{"id":6084,"href":"https:\/\/www.functionalps.com\/blog\/wp-json\/wp\/v2\/posts\/6082\/revisions\/6084"}],"wp:attachment":[{"href":"https:\/\/www.functionalps.com\/blog\/wp-json\/wp\/v2\/media?parent=6082"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.functionalps.com\/blog\/wp-json\/wp\/v2\/categories?post=6082"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.functionalps.com\/blog\/wp-json\/wp\/v2\/tags?post=6082"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}