{"id":6265,"date":"2012-07-16T18:54:41","date_gmt":"2012-07-17T01:54:41","guid":{"rendered":"http:\/\/www.functionalps.com\/blog\/?p=6265"},"modified":"2014-02-15T14:08:36","modified_gmt":"2014-02-15T22:08:36","slug":"sodium-deficiency-in-preeclampsia","status":"publish","type":"post","link":"https:\/\/www.functionalps.com\/blog\/2012\/07\/16\/sodium-deficiency-in-preeclampsia\/","title":{"rendered":"Sodium Deficiency in Pre-eclampsia"},"content":{"rendered":"

Also see:
\nRole of Serotonin in Preeclampsia<\/a>
\nAldosterone, Sodium Deficiency, and Insulin Resistance<\/a>
\nThe Randle Cycle<\/a>
\nFree Fatty Acids Suppress Cellular Respiration<\/a>
\nAldosterone as an endogenous cardiovascular toxin<\/a>
\nAldosterone and Thrombosis<\/a>
\nSodium Deficiency and Stress<\/a>
\nLow Sodium Diet: High FFA, Insulin Resistance, Atherosclerosis
\n<\/a><\/p>\n

BJOG. 2004 Sep;111(9):1020-2.
\nSevere hyponatraemia and pre-eclampsia.<\/a>
\n<\/strong>Burrell C, de Swiet M.
\n“This case report showed severe hyponatraemia complicating pre-eclampsia in a patient with normal urine sodium and potassium excretion and urine osmolality but with decreased plasma osmolality.”<\/p>\n

Am J Obstet Gynecol. 1998 Nov;179(5):1312-6.
\nDilutional hyponatremia in pre-eclampsia.<\/a>
\n<\/strong>Hayslett JP, Katz DL, Knudson JM.
\nOBJECTIVE:
\nThe objective of this report is to describe a defect in water metabolism, characterized by hyponatremia, in patients with pre-eclampsia-induced nephrotic syndrom.
\nSTUDY DESIGN:
\nThis was an observational study of 3 women.
\nRESULTS:
\nHyponatremia was observed in 3 women with pre-eclampsia characterized by various extrarenal manifestations, as well as by nephrotic syndrome with normal or nearly normal renal function. <\/strong>Restriction in water intake partially corrected hyponatremia before delivery in each case, and no complications were observed in the neonates. The mechanism of impaired excretion of water in these patients is proposed to involve persistent and inappropriate production of vasopressin through stimulation of the nonosmotic mechanism for vasopressin secretion in response to a reduction in effective plasma volume.
\nCONCLUSIONS:
\nThese results indicate for the first time that women with pre-eclampsia are, at least when nephrotic, at risk for development of dilutional hyponatremia, which can cause neurologic complications that simulate those of eclampsia.<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

Also see: Role of Serotonin in Preeclampsia Aldosterone, Sodium Deficiency, and Insulin Resistance The Randle Cycle Free Fatty Acids Suppress Cellular Respiration Aldosterone as an endogenous cardiovascular toxin Aldosterone and Thrombosis Sodium Deficiency and Stress Low Sodium Diet: High FFA, Insulin Resistance, Atherosclerosis BJOG. 2004 Sep;111(9):1020-2. Severe hyponatraemia and pre-eclampsia. Burrell C, de Swiet M. […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[567,568,1530,1355,782,586,537,1529],"class_list":["post-6265","post","type-post","status-publish","format-standard","hentry","category-general","tag-high-blood-pressure","tag-hypertension","tag-hyponatremia","tag-preeclampsia","tag-pregnancy","tag-salt","tag-sodium","tag-toxemia"],"_links":{"self":[{"href":"https:\/\/www.functionalps.com\/blog\/wp-json\/wp\/v2\/posts\/6265","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.functionalps.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.functionalps.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.functionalps.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.functionalps.com\/blog\/wp-json\/wp\/v2\/comments?post=6265"}],"version-history":[{"count":9,"href":"https:\/\/www.functionalps.com\/blog\/wp-json\/wp\/v2\/posts\/6265\/revisions"}],"predecessor-version":[{"id":10422,"href":"https:\/\/www.functionalps.com\/blog\/wp-json\/wp\/v2\/posts\/6265\/revisions\/10422"}],"wp:attachment":[{"href":"https:\/\/www.functionalps.com\/blog\/wp-json\/wp\/v2\/media?parent=6265"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.functionalps.com\/blog\/wp-json\/wp\/v2\/categories?post=6265"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.functionalps.com\/blog\/wp-json\/wp\/v2\/tags?post=6265"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}