{"id":6737,"date":"2012-09-19T15:12:52","date_gmt":"2012-09-19T22:12:52","guid":{"rendered":"http:\/\/www.functionalps.com\/blog\/?p=6737"},"modified":"2013-06-24T18:42:56","modified_gmt":"2013-06-25T01:42:56","slug":"serotonin-and-melatonin-lower-progesterone","status":"publish","type":"post","link":"https:\/\/www.functionalps.com\/blog\/2012\/09\/19\/serotonin-and-melatonin-lower-progesterone\/","title":{"rendered":"Serotonin and Melatonin Lower Progesterone"},"content":{"rendered":"

Also see:
\nMelatonin Lowers Body Temperature<\/a>
\nTryptophan, Sleep, and Depression<\/a>
\nCarbohydrate Lowers Free Tryptophan<\/a>
\nGelatin > Whey<\/a>
\nSerotonin, Fatigue, Training, and Performance<\/a>
\nGelatin, Glycine, and Metabolism<\/a>
\nWhey, Tryptophan, & Serotonin<\/a>
\nTryptophan Metabolism: Effects of Progesterone, Estrogen, and PUFA
\n<\/a><\/p>\n

In 1994 A.V. Sirotkin found that melatonin inhibits progesterone production but stimulates estrogen production, and it\u2019s widely recognized that melatonin generally inhibits the thyroid hormones, creating an environment in which fertilization, implantation, and development of the embryo are not possible. This combination of high estrogen with low progesterone and low thyroid decreases the resistance of the organism, predisposing it to seizures and excitotoxic damage, and causing the thymus gland to atrophy.<\/em> -Ray Peat, PhD<\/p>\n

Although melatonin sometimes antagonizes serotonin in a protective way, in itself it can lower body temperature and alertness, suppressing thyroid and progesterone. (Sirotkin, 1997)<\/em> -Ray Peat, PhD<\/p>\n

Exp Clin Endocrinol Diabetes. 1997;105(2):109-12.
\nMelatonin and serotonin regulate the release of insulin-like growth factor-I, oxytocin and progesterone by cultured human granulosa cells.<\/a>
\n<\/strong>Schaeffer HJ, Sirotkin AV.
\nThe direct influence of indoleamines on ovarian peptide hormones and growth factor secretion, in contrast to steroidogenesis, is yet to be thoroughly investigated. The aim of our in vitro experiments was to investigate the influence of melatonin and serotonin (5-hydroxy-tryptamine) (0.01-10 micrograms\/ml) on the release of insulin-like growth factor-I (IGF-I), oxytocin and progesterone by cultured human granulosa cells. It was observed that both melatonin and serotonin stimulate IGF-I release. Melatonin also stimulated oxytocin output. Serotonin increased oxytocin secretion only at the highest dose (10 micrograms\/ml). Both melatonin and serotonin were potent inhibitors of progesterone release.<\/strong> The present results suggest a possible involvement of the indoleamines melatonin and serotonin in the direct regulation of growth factor, nonapeptide and steroid hormone secretion by human ovarian cells.<\/p>\n","protected":false},"excerpt":{"rendered":"

Also see: Melatonin Lowers Body Temperature Tryptophan, Sleep, and Depression Carbohydrate Lowers Free Tryptophan Gelatin > Whey Serotonin, Fatigue, Training, and Performance Gelatin, Glycine, and Metabolism Whey, Tryptophan, & Serotonin Tryptophan Metabolism: Effects of Progesterone, Estrogen, and PUFA In 1994 A.V. Sirotkin found that melatonin inhibits progesterone production but stimulates estrogen production, and it\u2019s widely […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[389,461,6,453,460,142,1170],"class_list":["post-6737","post","type-post","status-publish","format-standard","hentry","category-general","tag-gelatin","tag-melatonin","tag-progesterone","tag-ray-peat","tag-serotonin","tag-thyroid","tag-tryptophan"],"_links":{"self":[{"href":"https:\/\/www.functionalps.com\/blog\/wp-json\/wp\/v2\/posts\/6737","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.functionalps.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.functionalps.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.functionalps.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.functionalps.com\/blog\/wp-json\/wp\/v2\/comments?post=6737"}],"version-history":[{"count":6,"href":"https:\/\/www.functionalps.com\/blog\/wp-json\/wp\/v2\/posts\/6737\/revisions"}],"predecessor-version":[{"id":9564,"href":"https:\/\/www.functionalps.com\/blog\/wp-json\/wp\/v2\/posts\/6737\/revisions\/9564"}],"wp:attachment":[{"href":"https:\/\/www.functionalps.com\/blog\/wp-json\/wp\/v2\/media?parent=6737"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.functionalps.com\/blog\/wp-json\/wp\/v2\/categories?post=6737"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.functionalps.com\/blog\/wp-json\/wp\/v2\/tags?post=6737"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}