{"id":7475,"date":"2012-11-06T18:02:30","date_gmt":"2012-11-07T02:02:30","guid":{"rendered":"http:\/\/www.functionalps.com\/blog\/?p=7475"},"modified":"2017-01-08T19:09:16","modified_gmt":"2017-01-09T03:09:16","slug":"comparison-carbon-dioxide-v-lactic-acid","status":"publish","type":"post","link":"https:\/\/www.functionalps.com\/blog\/2012\/11\/06\/comparison-carbon-dioxide-v-lactic-acid\/","title":{"rendered":"Comparison: Carbon Dioxide v. Lactic Acid"},"content":{"rendered":"

Also see:<\/strong>
\nCarbon Dioxide Basics<\/a>
\nUniversal Principle of Cellular Energy<\/a>
\nCarbon Dioxide as an Antioxidant<\/a>
\nComparison: Oxidative Metabolism v. Glycolytic Metabolic<\/a>
\nThe Glucose Song<\/a>
\nPromoters of Efficient v. Inefficient Metabolism<\/a>
\nTrauma & Resuscitation: Toxicity of Lactated Ringer’s Solution<\/a>
\nAltitude Sickness: Therapeutic Effects of Acetazolamide and Carbon Dioxide<\/a>
\nLow CO2 in Hypothyroidism<\/a>
\nProtective Altitude<\/a>
\nProtect the Mitochondria<\/a>
\nLactate Paradox: High Altitude and Exercise<\/a>
\nAltitude Improves T3 Levels
\n<\/a>Protective Carbon Dioxide, Exercise, and Performance
\n<\/a>Synergistic Effect of Creatine and Baking Soda on Performance<\/a>
\nRay Peat, PhD on Carbon Dioxide, Longevity, and Regeneration<\/a>
\nMitochondria & Mortality<\/a>
\nAltitude and Mortality<\/a>
\nLactate: a metabolic key player in cancer<\/a><\/p>\n

Quotes by Ray Peat, PhD:<\/strong>
\n“Lactic acid and carbon dioxide have opposing effects.”<\/em><\/p>\n

\u201cOxidation of sugar is metabolically efficient in many ways, including sparing oxygen consumption. It produces more carbon dioxide than oxidizing fat does, and carbon dioxide has many protective functions, including increasing Krebs cycle activity and inhibiting toxic damage to proteins.\u201d<\/em><\/p>\n

“If the oxidative metabolism of a cell is compared to a flame, lactic acid is the smoke that’s produced when there isn’t enough oxygen, or when the temperature is too low. Both a cell and a flame produce produce carbon dioxide when nothing interferes with their oxidation.”<\/em><\/p>\n

The end product of respiration is carbon dioxide, and it is an essential component of the life process. The ability to produce and retain enough carbon dioxide is as important for longevity as the ability to conserve enough heat to allow chemical reactions to occur as needed.<\/em><\/p>\n

“Sugar can be used to produce energy with or without oxygen, but oxidative metabolism is about 15 times more efficient than the non-oxidative “glycolytic” or fermentive metabolism; higher organisms depend on this high efficiency oxidation for maintaining integration and normal functioning: If there is a small interference with respiration, the organism can adapt by increasing the rate of glycolysis, but there must be enough sugar to meet the demand. A response to stimulation is the production of more energy, with a proportional increase of oxygen and sugar consumption by the stimulated tissue; this produces more carbon dioxide. which enlarges the blood vessels in the area, providing more sugar and oxygen. If the irritation becomes destructive, efficiency is lost: oxygen is either consumed wastefully, causing blueness of the tissue (assuming circulation continues: blueness can also indicate bad circulation), or is not consumed. causing redness of the tissue. As more sugar is consumed in compensation , lactic acid also enlarges the blood vessels.<\/p>\n

If the inflamed or exhausted tissue is small, the lactic acid can be consumed by other oxidizing tissues, sufficient sugar usually can be supplied, and repair occurs. But a large inflammation. or profound exhaustion, will lower the blood sugar systemically, and will deliver large amounts of lactic acid to the liver. The liver synthesizes glucose from the lactic acid, but at the expense of about 6 times more energy than is obtained from the inefficient metabolism – so that organismically, that tissue becomes 90 times less efficient than its original state. Besides this, an idle destruction of energy molecules (ATP or creatine phosphate) will increase the wastefulness even more.”<\/em><\/p>\n

“Besides the simple excitotoxic killing of nerve cells, the processes which impair carbon dioxide production set in motion the long degenerative process that ranges from diabetic lacticacidemia to dementia.”<\/em><\/p>\n

“The balance between what a tissue needs and what it gets will govern the way that tissue functions, in both the short term and the long term. When a cell emits lactic acid and free radicals and the products of lipid peroxidation, it’s reasonable to assume that it isn’t getting everything that it needs, such as oxygen and glucose. With time, the cell will either die or adapt in some way to its deprived conditions.”<\/em><\/p>\n

\u201cIncreasing carbon dioxide lowers the intracellular pH, as well as inhibiting lactic acid formation, and restoring the oxidation of glucose increases CO2. Inhibiting carbonic anhydrase, to allow more CO2 to stay in the cell, contributes to intracellular acidification, and by systemically increasing carbon dioxide this inhibition has a broad range of protective anti-excitatory effects. The drug industry is now looking for chemicals that will specifically inhibit the carbonic anhydrase enzymes that are active in tumors. Existing carbonic anhydrase inhibitors, such as acetazolamide, will inhibit those enzymes, without harming other tissues. Aspirin has some effect as an inhibitor of carbonic anhydrase (Bayram, et al., 2008). Since histamine, serotonin (Vullo, et al., 2007), and estrogen (Barnett, et al., 2008; Garg, 1975) are carbonic anhydrase activators, their antagonists would help to acidify the hypoxic cells. Testosterone (Suzuki, et al., 1996) and progesterone are estrogen antagonists that inhibit carbonic anhydrase.\u201d<\/em><\/p>\n

“Thyroid is needed to keep the cell in an oxidative, rather than reductive state, and progesterone (which is produced elsewhere only when cells are in a rapidly oxidizing state) activates the processes that remove estrogen from the cell, and inactivates the processes that would form new estrogen in the cell.<\/p>\n

Thyroid, and the carbon dioxide it produces, prevent the formation of the toxic lactic acid. When there is enough carbon dioxide in the tissues, the cell is kept in an oxidative state, and the formation of toxic free radicals is suppressed. Carbon dioxide therapy is extremely safe.”
\n<\/em>
\n“Glycolysis is very inefficient for producing usable energy compared to the respiratory metabolism of the mitochondria, and when lactate is carried to the liver, its conversion to glucose adds to the energy drain on the organism.”
\n<\/em>
\n“These factors that impair respiration tend to shift mitochondrial metabolism away from the oxidation of glucose and the production of carbon dioxide, to the oxidation of fats and the production of lactic acid.”<\/em><\/p>\n

“The presence of carbon dioxide is an indicator of proper mitochondrial respiratory functioning.”<\/em><\/p>\n

“The presence of lactic acid, which indicates stress or defective respiration, interferes with energy metabolism in ways that tend to be self-promoting. Harry Rubin\u2019s experiments demonstrated that cells become cancerous before genetic changes appear. The mere presence of lactic acid can make cells more susceptible to the transformation into cancer cells. (Mothersill, et al., 1983.)”<\/em><\/p>\n

“CO2 does help to reduce lactic acid production, but if there’s a chronic excess of lactic acid it’s most likely from a B vitamin deficiency or low thyroid function, or both. Muscles lose magnesium easily with those metabolic problems, so a diet with some well cooked greens (or just the water they boil in), orange juice, milk, and cheese, with liver and shell fish once a week, could help.”<\/em><\/p>\n

\u201cThe features of the stress metabolism include increases of stress hormones, lactate, ammonia, free fatty acids, and fat synthesis, and a decrease in carbon dioxide. Factors that lower the stress hormones, increase carbon dioxide, and help to lower the circulating free fatty acids, lactate, and ammonia, include vitamin B1 (to increase CO2 and reduce lactate), niacinamide (to reduce free fatty acids), sugar (to reduce cortisol, adrenaline, and free fatty acids), salt (to lower adrenaline), thyroid hormone (to increase CO2). Vitamins D, K, B6 and biotin are also closely involved with carbon dioxide metabolism. Biotin deficiency can cause aerobic glycolysis with increased fat synthesis (Marshall, et al., 1976).\u201d <\/em><\/p>\n

\"\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Also see: Carbon Dioxide Basics Universal Principle of Cellular Energy Carbon Dioxide as an Antioxidant Comparison: Oxidative Metabolism v. Glycolytic Metabolic The Glucose Song Promoters of Efficient v. Inefficient Metabolism Trauma & Resuscitation: Toxicity of Lactated Ringer’s Solution Altitude Sickness: Therapeutic Effects of Acetazolamide and Carbon Dioxide Low CO2 in Hypothyroidism Protective Altitude Protect the […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[768,23,547,548,2006,1371,301,1218,1671,397,396,1066,453,1603],"class_list":["post-7475","post","type-post","status-publish","format-standard","hentry","category-general","tag-bohr-effect","tag-cancer","tag-carbon-dioxide","tag-co2","tag-cytoplasm","tag-dementia","tag-diabetes","tag-glycolysis","tag-haldane-effect","tag-lactate","tag-lactic-acid","tag-oxidative-metabolism","tag-ray-peat","tag-warburg-effect"],"_links":{"self":[{"href":"https:\/\/www.functionalps.com\/blog\/wp-json\/wp\/v2\/posts\/7475","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.functionalps.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.functionalps.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.functionalps.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.functionalps.com\/blog\/wp-json\/wp\/v2\/comments?post=7475"}],"version-history":[{"count":35,"href":"https:\/\/www.functionalps.com\/blog\/wp-json\/wp\/v2\/posts\/7475\/revisions"}],"predecessor-version":[{"id":11762,"href":"https:\/\/www.functionalps.com\/blog\/wp-json\/wp\/v2\/posts\/7475\/revisions\/11762"}],"wp:attachment":[{"href":"https:\/\/www.functionalps.com\/blog\/wp-json\/wp\/v2\/media?parent=7475"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.functionalps.com\/blog\/wp-json\/wp\/v2\/categories?post=7475"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.functionalps.com\/blog\/wp-json\/wp\/v2\/tags?post=7475"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}