Organ Donor and Transplantation – Effects of “EFA” Deficiency

Also see:
Protective “Essential Fatty Acid Deficiency”
“Curing” a High Metabolic Rate with Unsaturated Fats
Fat Deficient Animals – Activity of Cytochrome Oxidase
Anti-Inflammatory Omega -9 Mead Acid (Eicosapentaenoic acid)
Errors in Nutrition: Essential Fatty Acids
Arachidonic Acid’s Role in Stress and Shock
PUFA, Development, and Allergy Incidence
PUFA Accumulation & Aging
Metabolism, Brain Size, and Lifespan in Mammals
“Curing” a High Metabolic Rate with Unsaturated Fats
Glucocorticoids, Cytochrome Oxidase, and Metabolism
Fat Deficient Animals – Activity of Cytochrome Oxidase
Toxicity of Stored PUFA

Animals that have a diet free of polyunsaturated fats are good organ donors and recipients. -Ray Peat, PhD (personal correspondence)

Science. 1988 May 20;240(4855):1032-3.
Essential fatty acid depletion of renal allografts and prevention of rejection.
Schreiner GF, Flye W, Brunt E, Korber K, Lefkowith JB.
A central hypothesis in transplantation biology is that resident leukocytes expressing class II histocompatibility antigens may determine the immunogenicity of an organ. By means of a novel method to deplete the kidney of resident leukocytes, essential fatty acid deficiency (EFAD), this hypothesis was tested in an intact, vascular organ. Kidneys subjected to EFAD and thus depleted of resident Ia-positive macrophages survived and functioned when transplanted across a major histocompatibility antigen barrier in the absence of immunosuppression of the recipient. Control allografts were rejected promptly. Allografts from donors subjected to EFAD normalized their lipid composition and were repopulated with host macrophages by 5 days. Administration of Ia-positive cells at the time of transplantation established that the resident leukocyte depletion induced by EFAD was responsible for the protective effect. These observations may provide insights into the mechanisms underlying tissue immunogenicity and the population of normal tissues with resident leukocytes.

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