Also see: The Streaming Organism The Randle Cycle Stem Cells. 2010 Sep;28(9):1630-8. Pancreatic β-cell neogenesis by direct conversion from mature α-cells. Chung CH, Hao E, Piran R, Keinan E, Levine F. Because type 1 and type 2 diabetes are characterized by loss of β-cells, β-cell regeneration has garnered great interest as an approach to diabetes [...]
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Also see: Fish Oil Toxicity PUFA, Fish Oil, and Alzheimers Women are known to have a greater susceptibility than men to lipolysis, with higher levels of free fatty acids in the serum and liver, because of the effects of estrogen and related hormones. Women on average have more DHA circulating in the serum than men [...]
Thymocytes are much more easily killed by stress than nerve cells, and they are easy to study. The PUFA kill them by increasing their intracellular calcium. The toxicity of DHA is greater than that of EPA, whose toxicity is greater than the alpha-linoleic acid, and linoleic acid was the most potent (Prasad, et al., 2010)…The [...]
One of the essential protective functions that decline with aging is the liver’s ability to detoxify chemicals, by combining them by glucuronic acid, making them water soluble so that they can be excreted in the urine. The liver (and also the instestines and stomach) efficiently process DHA by glucuronidation. -Ray Peat, PhD Drug Metab Dispos. [...]
One of the essential protective functions that decline with aging is the liver’s ability to detoxify chemicals, by combining them by glucuronic acid, making them water soluble so that they can be excreted in the urine. The liver (and also the instestines and stomach) efficiently process DHA by glucuronidation. -Ray Peat, PhD Drug Metab Dispos. [...]
Exp Gerontol. 2005 Apr;40(4):335-43. Unsaturated fatty acids intake and all-causes mortality: a 8.5-year follow-up of the Italian Longitudinal Study on Aging. Solfrizzi V, D’Introno A, Colacicco AM, Capurso C, Palasciano R, Capurso S, Torres F, Capurso A, Panza F. Recent evidence suggested a protective role of dietary monounsaturated fatty acids (MUFA) and polyunsaturated fatty acids [...]
The least stable n-3 fats which accumulate with age and gradually reduce energy production also have their short term effects on endurance. Endurance was much lower in rats fed a high n-3 fat dit, and the effect persisted even after 6 weeks on a standard diet (Ayre and Hulbert, 1997). -Ray Peat, PhD Lipids. 1997 [...]
