Also see: Intestinal Serotonin and Bone Loss Serotonin and Melatonin Lower Progesterone Role of Serotonin in Preeclampsia Maternal Ingestion of Tryptophan and Cancer in Female Offspring Melatonin Lowers Body Temperature Tryptophan, Sleep, and Depression Carbohydrate Lowers Free Tryptophan Gelatin > Whey Serotonin, Fatigue, Training, and Performance Gelatin, Glycine, and Metabolism Whey, Tryptophan, & Serotonin Omega [...]
“An excess of tryptophan in the diet, especially with deficiencies of other nutrients, can combine with inflammation to increase serotonin. Polyunsaturated fatty acids promote the absorption of tryptophan by the brain, and its conversion to serotonin. A “deficiency” of polyunsaturated fat decreases the expression of the enzyme that synthesizes serotonin (McNamara, et al., 2009). -Ray [...]
Hypothyroidism is a very common cause of increased serotonin (e.g. Henley, et al., 1998), and it the thyroid hormone is supplemented until symptoms are resolved, it’s likely that the serotonin will have been normalized. -Ray Peat, PhD Hypothyroidism increases the formation of serotonin, as does cortisol (Henley, et al., 1997, 1998; Neckers and Sze, 1976). [...]
Since estrogen promotes serotonin, progesterone is likely to be a protective factor (Donner & Handa, 2009; Hiroi, et al., 2006; Berman, et al., 2006; Bethea, et al., 2000). -Ray Peat, PhD Neuroscience. 2009 Oct 6;163(2):705-18. Epub 2009 Jun 23. Estrogen receptor beta regulates the expression of tryptophan-hydroxylase 2 mRNA within serotonergic neurons of the rat [...]
