Free fatty acids suppress mitochondrial respiration (Kamikawa and Yamazaki, 1981), leading to increased glycolysis (producing lactic acid) to maintain cellular energy. The suppression of mitochondrial respiration increase the production of toxic free radicals, and the decreased carbon dioxide makes the proteins more susceptible to attack by free radicals. -Ray Peat, PhD Jpn Heart J. 1981 [...]
Carbon dioxide (CO2) is the key player in O2 transport due to 1) vasodilation and 2) the the Bohr effect (or the Bohr law). The Bohr effect explains oxygen release in capillaries or why red blood cells unload oxygen in tissues. The Bohr effect was first described in 1904 by the Danish physiologist Christian Bohr [...]
