Browsing articles in "mitochondria"
Also see: Protect the Mitochondria Mitochondria and mortality Power Failure: Does mitochondrial dysfunction lie at the heart of common, complex diseases like cancer and autism? J Intern Med. 1995 Nov;238(5):405-21. Mitochondrial medicine Luft R, Landau BR. In the mitochondrion, inherited defects have been identified in the electron transport system by which ATP is formed, as [...]
Also see: High Cholesterol and Metabolism The Cholesterol and Thyroid Connection Thyroid Status and Oxidized LDL The Truth about Low Cholesterol Hypothyroidism and A Shift in Death Patterns Light is Right Using Sunlight to Sustain Life PUFA Decrease Cellular Energy Production PUFA Breakdown Products Depress Mitochondrial Respiration “Curing” a High Metabolic Rate with Unsaturated Fats [...]
Energy depletion itself is an excitatory state, that calls for increased fuel and oxygen. But when cells are exposed to PUFA, their ability to use glucose is blocked, increasing their exposure to the fats. Saturated fats activate the pyruvate dehydrogenase enzyme that is essential for the efficient use of glucose, while PUFA block it. -Ray Peat, [...]
Also see: Lactate Paradox: High Altitude and Exercise Altitude Improves T3 Levels Protective Carbon Dioxide, Exercise, and Performance Synergistic Effect of Creatine and Baking Soda on Performance Ray Peat, PhD on Carbon Dioxide, Longevity, and Regeneration People who live at very high altitudes live significantly longer; they have a lower incidence of cancer (Weinberg, et [...]
Also see: PUFA – Accumulation & Aging Free Fatty Acids Suppress Cellular Respiration “Curing” a High Metabolic Rate with Unsaturated Fats Fat Deficient Animals – Activity of Cytochrome Oxidase Randle Cycle Protective “Essential Fatty Acid Deficiency” Errors in Nutrition: Essential Fatty Acids With aging, cells have less ability to produce energy, and are often more [...]
Also see: Unsaturated Fats and Longevity “Curing” a High Metabolic Rate with Unsaturated Fats A living cell requires energy not only for all its functions, but also for the maintenance of its structure. -Albert Szent-Gyorgyi The brain has a high rate of oxidative metabolism, and so it forms a very large proportion of the carbon [...]
Also see – The Truth about Low Cholesterol Anything that increases lactic acid production, thus lowering energy production, is fundamentally unhealthy. -Byron Richards Br J Clin Pharmacol. 1996 Sep;42(3):333-7. Lipid-lowering drugs and mitochondrial function: effects of HMG-CoA reductase inhibitors on serum ubiquinone and blood lactate/pyruvate ratio. De Pinieux G, Chariot P, Ammi-Saïd M, Louarn F, [...]
Free fatty acids suppress mitochondrial respiration (Kamikawa and Yamazaki, 1981), leading to increased glycolysis (producing lactic acid) to maintain cellular energy. The suppression of mitochondrial respiration increase the production of toxic free radicals, and the decreased carbon dioxide makes the proteins more susceptible to attack by free radicals. -Ray Peat, PhD Jpn Heart J. 1981 [...]
Also see: PUFA, Fish Oil, and Alzheimers Biochemistry. 1998 Jan 13;37(2):552-7. Inhibition of NADH-linked mitochondrial respiration by 4-hydroxy-2-nonenal. Humphries KM, Yoo Y, Szweda LI. During the progression of certain degenerative conditions, including myocardial ischemia-reperfusion injury, mitochondria are a source of increased free-radical generation and exhibit declines in respiratory function(s). It has therefore been suggested that [...]
